Therapeutic approaches to gastroesophageal junction adenocarcinomas.

Current therapeutic approaches to localized carcinoma of the esophagus and gastroesophageal junction

Epigenetic Subgroups of Esophageal and Gastric Adenocarcinoma with Differential GATA5 DNA Methylation Associated with Clinical and Lifestyle Factors

BACKGROUND Adenocarcinomas located near the gastroesophageal junction have unclear etiology and are difficult to classify. We used DNA methylation analysis to identify subtype-specific markers and new subgroups of gastroesophageal adenocarcinomas, and studied their association with epidemiological risk factors and clinical outcomes. METHODOLOGY/PRINCIPAL FINDINGS We used logistic regression m...

BARRETT’S ESOPHAGUS AND ASSOCIATED ADENOCARCINOMA - Studies on pathogenesis, clinical staging, and cost-utility of cancer treatment

.................................................................................................................... 8 INTRODUCTION ......................................................................................................... 10 REVIEW OF THE LITERATURE ................................................................................. 12 1. Barrett’s esophagus ..........................

Prognostic Importance and Therapeutic Implications of PAK1, a Drugable Protein Kinase, in Gastroesophageal Junction Adenocarcinoma

Gastroesophageal junction (GEJ) adenocarcinoma is a lethal cancer with rising incidence, yet the molecular biomarkers that have strong prognostic impact and also hold great therapeutic promise remain elusive. We used a data mining approach and identified the p21 protein-activated kinase 1 (PAK1), an oncogene and drugable protein kinase, to be among the most promising targets for GEJ adenocarcin...

Management of gastroesophageal tumors.

The incidence of adenocarcinomas of the gastroesophageal junction has increased in recent years. These tumors possess distinct pathophysiologic characteristics. Although the consensus is that an R0 resection (complete microscopic and macroscopic resection) is the goal when operating for curative intent, much controversy remains regarding other aspects of patient management. There is lack of con...